Medical Research

2013 ICRA Grantees

Genome Editing of the GWAS-Marked BCL11A Enhancer: An Approach to HbF Reactivation in Sickle Cell Disease

  • Daniel E. Bauer, M.D., Ph.D. and Stuart H Orkin, M.D. 
    Children’s Hospital, Boston and Harvard Medical School

Examination of Human Samples with Somatic Mutations in Hematopoietic Stem Cells to Inform the Biology of Fetal Hemoglobin Induction

  • Benjamin L. Ebert, M.D., Ph.D. and Maureen M. Okam, M.D., M.P.H. 
    Brigham and Women's Hospital and Harvard Medical School

"SCD Biochip": Towards a Simple and Reliable Way to Monitor Sickle Cell Disease

  • Umut A. Gurkan, Ph.D. and Jane A. Little, M.D.
    Case Western Reserve University

Feasibility and Efficacy of a Home-Based, Computerized Cognitive Training Program in Pediatric Sickle Cell Disease

  • Steven J. Hardy, Ph.D. and Kristina K. Hardy, Ph.D. 
    Children’s National Medical Center

Novel Use Of Hydroxyurea in an African Region with Malaria

  • Chandy C. John, M.D. 
    University of Minnesota

The Effects of Hypoxia on Red Blood Cell-Dependent Thrombin Generation in Sickle Cell Disease

  • Nigel S. Key, MB ChB and Kenneth Mann, M.D. 
    University of North Carolina at Chapel Hill and University of Vermont 

Site-Specific Gene Modification in Hematopoietic Stem Cells for Sickle Cell Disease

  • Donald Kohn, M.D. 
    University of California, Los Angeles 

Gene Therapy for Sickle Cell Anemia

  • Punam Malik, M.D.
    Cincinnati Children's Hospital Medical Center

Targeting Neutrophil Extracellular Traps in Sickle Cell Disease

  • Leslie V. Parise, Ph.D. and Bruce A. Sullenger, Ph.D. 
    University of North Carolina at Chapel Hill and Duke University Medical Center

Accurate and Inexpensive Point-of-Care Diagnosis of Sickle Cell Anemia

  • Rebecca R. Richards-Kortum, Ph.D. 
    William Marsh Rice University      

Risk Stratification for Clinical Severity of Sickle Cell Disease in Nigeria and Assessment of Efficacy and Safety during Treatment with Hydroxyurea

  • Bamidele Tayo, Ph.D. and Victor R. Gordeuk, M.D.
    Loyola University of Chicago and University of Illinois at Chicago